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邻苯二甲酸酯(phthalate esters,PAEs)作为塑化剂广泛用于聚氯乙烯(PVC)塑料产品中,在环境中普遍存在,现已被确定为环境内分泌干扰物,主要通过食物、水、皮肤等途径进入机体。流行病学调查显示,邻苯二甲酸酯暴露与女性生殖系统损伤有关。邻苯二甲酸酯可干扰雌性啮齿类动物的排卵和卵巢颗粒细胞激素的分泌,并且可影响受精卵的着床及生长发育。该文综述了邻苯二甲酸酯类对雌性卵巢颗粒细胞、卵泡和子宫的影响及其可能的作用机制,并对目前存在的问题和未来研究的方向进行了展望。
Phthalate esters (PAEs), widely used as plasticizers in polyvinyl chloride (PVC) plastic products, are ubiquitous in the environment and have now been identified as environmental endocrine disruptors, mainly by food, water , Skin and other means into the body. Epidemiological survey shows that phthalate exposure and female reproductive system damage. Phthalates can interfere with female rodents ovulation and ovarian granulosa cells hormone secretion, and can affect the fertilized egg implantation and growth and development. This review summarizes the effects of phthalates on female ovarian granulosa cells, follicles and uterus and their possible mechanisms. The current problems and future research directions are also discussed.