论文部分内容阅读
本文用Hela细胞乳酸脱氢酶释放法测定了19例慢性乙肝病人外周血NK、ADCC活性以及rIL-2对它们的影响。结果表明,正常人外周血PBL经rIL-2500u/ml预培养18小时后NK、ADCC活性均显著升高(P<0.01,P<0.05);慢性迁延性肝炎病人(CPH)ADCC对rIL-2呈明显增强反应(P<0.05),但NK活性无明显改变;慢性活动性肝炎病人(CAH)则NK活性对rIL-218小时培养后有明显的增强(P<0.05),ADCC活性无变化;11例CAH PBL经rIL-2500u/ml预处理4小时其NK活性即有非常显著的升高(P<0.001),而且这种增强作用在rIL-2500u/ml以内随rIL-2浓度增大而增强。IFN-α和rIL-2具有协同增强乙肝病人NK、ADCC活性之作用。
In this paper, Hela cell lactate dehydrogenase release method was used to determine the activity of NK and ADCC in 19 chronic hepatitis B patients and the effect of rIL-2 on them. The results showed that the activity of NK and ADCC in PBL of normal people were significantly increased after being pre-incubated with rIL-2500u / ml for 18 hours (P <0.01, P <0.05). The ADCC of chronic persistent hepatitis (CPH) (P <0.05), but there was no significant change in NK activity. In chronic active hepatitis (CAH), NK activity was significantly increased after rIL-218 h incubation (P <0.05) 11 cases of CAH PBL pretreatment with rIL-2500u / ml 4 hours had a very significant increase in NK activity (P <0.001), and this enhancement with rIL-2500u / ml increased with rIL-2 concentration Enhanced. IFN-α and rIL-2 synergistically enhance the activity of NK and ADCC in hepatitis B patients.