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目的分析芬太尼透皮贴剂在癌痛患者治疗中的药理特点及应用效果。方法选取2015年溧阳市人民医院收治的癌性疼痛患者207例,随机分为观察组104例与对照组103例。观察组给予芬太尼透皮贴剂治疗,对照组给予硫酸吗啡缓释片治疗,比较两组患者疼痛治疗效果、生活质量评分及不良反应发生率。结果两组患者总有效率比较,差异无统计学意义(P>0.05)。治疗前两组患者生活质量评分比较,差异无统计学意义(P>0.05);治疗后观察组生活质量评分高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论芬太尼透皮贴剂在癌性疼痛患者镇痛治疗中的应用效果明显,能够较好地缓解患者疼痛,有效改善患者睡眠情况、心理状态,增加其治疗积极性,提高患者生活质量,且不良反应少。
Objective To analyze the pharmacological characteristics and the application effect of fentanyl transdermal patch in the treatment of cancer patients. Methods A total of 207 patients with cancer pain who were admitted to Liyang People’s Hospital in 2015 were randomly divided into observation group (104 cases) and control group (103 cases). The observation group was treated with transdermal patch of fentanyl, the control group was treated with morphine sulfate sustained-release tablets, and the pain treatment, quality of life score and incidence of adverse reactions were compared between the two groups. Results There was no significant difference in the total effective rate between the two groups (P> 0.05). There was no significant difference in quality of life between the two groups before treatment (P> 0.05). After treatment, the quality of life scores of the observation group were higher than those of the control group, and the incidence of adverse reactions was lower than that of the control group (P < 0.05). Conclusion The application of transdermal fentanyl in the analgesic treatment of patients with cancerous pain is effective and effective in relieving the pain of patients and effectively improving their sleep status and psychological status, increasing their enthusiasm for treatment and improving their quality of life Adverse reactions.