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慢性进行性多发性硬化(CPMS)的抑制性T细胞(TS)上的β—肾上腺素能受体(βR)密度是增高的。作者对CPMS患者和正常人(NL)的高亲和性βR对非颗粒型白细胞亚群的环磷酸腺苷(cAMP)应答所起的作用进行了研究。发现在CPMS中CD8βR的密度为1930个受体/细胞而NL中仅1020个受体/细胞(t(18)=2.73,P<0.02)。单核细胞,B细胞和CD4细胞上的。βR密度两组间无差异。CPMS中CD_8细胞上βR密度的增高完全是因高亲和性受体数量增多所致。在CPMS中,CD_8淋巴细胞的CAMP基础水平为7.8pmol/10~6个细胞,而在NL中为3.5pmol/10~6个细胞。异丙肾上腺素(iso-
The density of β-adrenergic receptor (βR) on suppressor T cells (TS) in chronic progressive multiple sclerosis (CPMS) is increased. The authors investigated the role of high-affinity βR in CPMS patients and normal individuals (NL) in responding to cyclic adenosine monophosphate (cAMP) responses in non-granular leukocyte subsets. CD8βR was found to have a density of 1930 receptors / cell in CPMS compared to only 1020 receptors / cell in NL (t (18) = 2.73, P <0.02). Monocytes, B cells and CD4 cells. There was no difference in βR density between the two groups. The increase in βR density on CD_8 cells in CPMS was entirely due to the increased number of high-affinity receptors. In CPMS, CD_8 lymphocytes have a CAMP basal level of 7.8 pmol / 10 to 6 cells compared to 3.5 pmol / 10 to 6 cells in NL. Isoproterenol (iso-