【摘 要】
：
目的:在人微粒体中验证射干合剂中麻黄碱与利多卡因合用体外孵育时代谢酶.方法:采用人微粒体体外孵育法,高效液相色谱法测定麻黄碱、利多卡因及其代谢产物浓度,对合用前后、
【机 构】
：
上海交通大学医学院附属新华医院,上海,200092
论文部分内容阅读
目的:在人微粒体中验证射干合剂中麻黄碱与利多卡因合用体外孵育时代谢酶.方法:采用人微粒体体外孵育法,高效液相色谱法测定麻黄碱、利多卡因及其代谢产物浓度,对合用前后、孵育前后原形药物及其代谢物进行比较.结果:根据Dixon作图法,表明麻黄碱和利多卡因合用符合竞争抑制.结论:射干合剂中含有麻黄碱成分,在临床使用中应注意药物的相互作用产生.“,”Objective:With human microsomes to test the SGHT of ephedrine and lidocaine in vitro incubation of metabolic enzymes.Methods:Using human microsomes in vitro incubation method,a HPLC-UV method was developed for determination of ephedrine,lidocaine and its metabolic product concentration;before and after drug combined,before and after incubation unchanged drug and its metabolites were compared.Results:According to Dixon mapping,showed that the combination of ephedrine and lidocaine in line with competitive inhibition.Conclusion:SGHT containing ephedrine,it should pay attention to drug interactions in clinical use.
其他文献
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
目的:观察泻痢合剂治疗小儿轮状病毒肠炎的疗效。方法:将100例小儿轮状病毒肠炎患儿随机分为治疗组与对照组各50例。治疗组予泻痢合剂治疗,对照组口服蒙脱石散。两组疗程均为
目的:为完善杨氏消炎止痛贴质量标准,建立杨氏消炎止痛贴中薄层色谱鉴别方法。方法:采用薄层色谱鉴别法对杨氏消炎止痛贴中赤芍和血竭进行定性鉴别。结果:处方中赤芍和血竭的
The vertical cable method for acquiring and processing pre-stack 3-D marine seismic data is based on the technology developed by the US Navy for antisubmarine w
《伤寒杂病论》是张仲景在多年临证实践经验的基础上总结而来,书中虽未提“护理”二字,但根据中医理论的整体观念,贯穿了大量的整体护理学思想.同时也丰富了现代护理学,为提
目的:观察通督开窍针刺法联合语言训练治疗缺血性中风失语症的临床效果.方法:将70例缺血性中风失语症患者随机分为治疗组和对照组,两组均接受常规临床治疗,并给予语言训练,治
目的:探讨平乐郭氏正骨治疗骨质疏松症的用药规律.方法:总结平乐郭氏正骨治疗骨质疏松症的常用中药方剂35首,常用中药45味,进行用药频率分析.结果:平乐郭氏正骨治疗骨质疏松
This study measured stable carbon and nitro- gen isotope ratios in phytoplankton, zooplankton, five inver- tebrates species, eight fishes species and three seab
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
简述了中医对糖尿病微循环障碍的认识,探讨了不同病程糖尿病与微循环障碍的关系及影响因素,归纳了糖尿病微循环障碍的中西医常用评价方法,分析当前研究中的优势与不足,并对中