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目的 探讨胃肠道原发性淋巴瘤的临床病理特征。方法 按 WHO (2 0 0 0年 )诊断标准 ,对 4 6例胃肠道原发淋巴瘤进行临床、病理组织形态观察、免疫组织化学标记 ,并结合文献复习。结果 4 6例胃肠道原发淋巴瘤 ,男∶女 =1.8∶ 1,发病年龄 4～ 77岁 ,以消化道症状和腹部包块为主诉。好发部位 :胃 15例 ,小肠 2 3例 ,大肠 8例。组织学类型 :4 6例均为非霍奇金淋巴瘤 (NHL) ,B细胞性淋巴瘤 38例占 82 .6 % ,其中粘膜相关淋巴组织型边缘区 B细胞淋巴瘤 (MAL T- type) 19例 ,弥漫性大 B细胞性淋巴瘤 (DL BCL ) 15例 ,滤泡性淋巴瘤 (FL ) 1例 ,套细胞淋巴瘤(MCL) 1例 ,Burkitt样淋巴瘤 2例 ,T细胞淋巴瘤 8例占 17.4 %。不同组织学类型的淋巴瘤其免疫表型和临床表现不同。结论 胃肠道原发性淋巴瘤具有其独特的临床病理特征 ,准确的组织学分型和临床分期对治疗具有重要指导意义
Objective To investigate the clinicopathological features of primary gastrointestinal lymphoma. Methods According to the diagnostic criteria of WHO (2000), 46 cases of primary gastrointestinal lymphoma were observed for clinical and histopathological features, and immunohistochemically, and reviewed in literature. Results 46 cases of primary gastrointestinal lymphoma, male: female = 1.8: 1, the age of onset of 4 to 77 years old, with gastrointestinal symptoms and abdominal mass as the main complaint. Good site: stomach in 15 cases, 23 cases of small intestine, large intestine in 8 cases. Histological types: 46 cases were non-Hodgkin’s lymphoma (NHL), 38 cases of B-cell lymphoma accounted for 82.6%, of which mucosa-associated lymphoid tissue B-cell lymphoma (MAL T-type) 19 cases, 15 cases of diffuse large B cell lymphoma (DLBCL), 1 case of follicular lymphoma (FL), 1 case of mantle cell lymphoma (MCL), 2 cases of Burkitt-like lymphoma, 8 cases accounted for 17.4%. Lymphomas of different histological types have different immunophenotypes and clinical manifestations. Conclusion Gastrointestinal primary lymphoma has its unique clinical and pathological features, accurate histological type and clinical stage of treatment is of great guiding significance