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本文测定了实验性HgCl2染毒小鼠SOD活性变化及应用脂质体包封EDTA(Liposome-ED-TA)和直接EDTA治疗前后的SOD活性恢复情况。结果表明,正常小鼠血清SOD活性为0.7096±0.1835μg/ml,汞染毒小鼠血清SOD活性为0.3793±0.0849μg/ml.显示汞染毒小鼠血清SOD活性显著降低(P<0.01)。直接应用EDTA治疗后血清SOD活性略有恢复(与正常鼠SOD比较P<0.05),而应用Liposome-EDTA治疗后SOD恢复明显,已接近正常鼠水平(与正常鼠SOD比较P>0.05),提示Liposome-EDTA可能具有较强的驱汞作用。
In this paper, we measured the changes of SOD activity in experimental HgCl2-treated mice and the recovery of SOD activity before and after treatment with liposome-encapsulated EDTA (EDTA-Liposome-ED-TA) and direct EDTA. The results showed that the serum SOD activity of normal mice was 0.7096 ± 0.1835μg / ml, while that of mercury-exposed mice was 0.3793 ± 0.0849μg / ml. It showed that the activity of SOD in serum of mice exposed to mercury was significantly decreased (P <0.01). The activity of SOD in serum was slightly recovered after treatment with EDTA (P <0.05 compared with SOD in normal rats), and SOD recovered obviously after treated with Liposome-EDTA, which was close to normal rats (P> 0.05). 05), suggesting that Liposome-EDTA may have a stronger role in excretion of mercury.