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本文测定了实验性ＨｇＣｌ２染毒小鼠ＳＯＤ活性变化及应用脂质体包封ＥＤＴＡ（Ｌｉｐｏｓｏｍｅ－ＥＤ－ＴＡ）和直接ＥＤＴＡ治疗前后的ＳＯＤ活性恢复情况。结果表明，正常小鼠血清ＳＯＤ活性为０．７０９６±０．１８３５μｇ／ｍｌ，汞染毒小鼠血清ＳＯＤ活性为０．３７９３±０．０８４９μｇ／ｍｌ．显示汞染毒小鼠血清ＳＯＤ活性显著降低（Ｐ＜０．０１）。直接应用ＥＤＴＡ治疗后血清ＳＯＤ活性略有恢复（与正常鼠ＳＯＤ比较Ｐ＜０．０５），而应用Ｌｉｐｏｓｏｍｅ－ＥＤＴＡ治疗后ＳＯＤ恢复明显，已接近正常鼠水平（与正常鼠ＳＯＤ比较Ｐ＞０．０５），提示Ｌｉｐｏｓｏｍｅ－ＥＤＴＡ可能具有较强的驱汞作用。
In this paper, we measured the changes of SOD activity in experimental HgCl2-treated mice and the recovery of SOD activity before and after treatment with liposome-encapsulated EDTA (EDTA-Liposome-ED-TA) and direct EDTA. The results showed that the serum SOD activity of normal mice was 0.7096 ± 0.1835μg / ml, while that of mercury-exposed mice was 0.3793 ± 0.0849μg / ml. It showed that the activity of SOD in serum of mice exposed to mercury was significantly decreased (P <0.01). The activity of SOD in serum was slightly recovered after treatment with EDTA (P <0.05 compared with SOD in normal rats), and SOD recovered obviously after treated with Liposome-EDTA, which was close to normal rats (P> 0.05). 05), suggesting that Liposome-EDTA may have a stronger role in excretion of mercury.