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目的:探讨心理因素对妇科恶性肿瘤患者血清VEGF水平的影响。方法:采用对照研究的方法,运用临床心理评定量表(LES、CS、SSRS)对妇科恶性肿瘤患者组(n=80)、健康对照组(n=80)病前遭遇的生活事件、应付方式及社会支持进行问卷调查,同时用ELISA方法检测两组对象血清中的VEGF的水平,分析心理因素与血清VEGF水平的关系。结果:恶性肿瘤组患者负性生活事件频数及消极应对明显高于健康对照组,P<0.01;而积极应对、客观支持、主观支持以及对支持的利用度均低于健康对照组,P<0.01;妇科恶性肿瘤组患者血清VEGF值高于同期健康组,P<0.01。负性事件和消积应对与VEGF水平呈正相关,r值分别为0.618和0.432,P值均<0.01。而积极应对、客观支持以及主观支持均与VEGF呈负相关。结论:负性生活事件、不良应对方式及低的社会支持可促进妇科恶性肿瘤患者血清中VEGF水平的增高,与妇科恶性肿瘤的发生、发展密切相关。
Objective: To investigate the influence of psychological factors on the level of serum VEGF in patients with gynecological malignancies. Methods: The control group was enrolled in the study. The clinical psychological assessment scale (LES, CS, SSRS) was used to evaluate the life events of patients with gynecologic malignancies (n = 80), healthy controls And social support questionnaire survey. At the same time, the level of VEGF in sera of two groups was detected by ELISA, and the relationship between psychological factors and serum VEGF levels was analyzed. Results: The frequencies of negative life events and negative coping in patients with malignant tumor were significantly higher than those in healthy controls (P <0.01), while those in active coping, objective support, subjective support and support were lower than those in healthy controls (P <0.01) The serum VEGF in gynecological malignant group was higher than that in the same period, P <0.01. Negative events and negative response and VEGF levels were positively correlated, r values were 0.618 and 0.432, P values were <0.01. Positive response, objective support and subjective support were negatively correlated with VEGF. Conclusion: Negative life events, adverse coping styles and low social support can promote the increase of serum VEGF in patients with gynecological malignancies, which is closely related to the occurrence and development of gynecological malignancies.