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为研究皮质激素能否减少离子碘化物造影剂的副反应,作者将6763二名使用常规碘造影剂的病人,随机分成4组,第一、二组造影前12小时和2小时各服强的松32mg,第三、四组使用安慰剂分别作为第一、二组的对照。结果表明,4组中各种副反应的发生率分别是6.4％、9.4％、9.0％和9.9％,即二次用皮质激素的第一组减少副反应效果最好。若将第一组与所报告的使用非离子碘化物造影剂的50642名病人比较,发生需治疗副反应的百分率分别是1.2％和0.9％,差别无显著性意义。作者认为,使用常规离子碘化物做静脉造影剂,如用药前
To investigate whether corticosteroids can reduce the adverse effects of ionic iodide contrast agents, the authors randomly divided 67,763 patients who used conventional iodinated contrast agents into four groups. The first and second groups took prednisone 12 hours and 2 hours before angiography. 32 mg. The third and fourth groups used placebo as the control for the first and second groups, respectively. The results showed that the incidence of various side effects in the four groups was 6.4%, 9.4%, 9.0% and 9.9%, respectively, that the first group of secondary corticosteroids had the best side effects. If the first group was compared with the reported 50,642 patients using non-ionic iodide contrast agents, the percentage of side effects requiring treatment was 1.2% and 0.9%, respectively, with no significant difference. The authors believe that the use of conventional ion iodide as intravenous contrast agent, such as before treatment