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目的 探讨新鲜羊膜移植术治疗角膜溃疡的可行性、手术方法和临床效果。方法 采用新鲜羊膜移植治疗角膜溃疡16眼,其中细菌性角膜溃疡6眼,病毒性角膜溃疡3眼,复发性蚕蚀性角膜溃疡2眼,大泡性角膜病变2眼,持续性角膜上皮缺损3眼。手术方法有:单层羊膜移植6眼,多层羊膜移植7眼,羊膜移植联合带活性角膜缘的板层角膜移植3眼。术后随访6-19月。结果 术后均未见新鲜羊膜移植片急性排斥反应,16眼中14眼治愈。术后3-15天,炎症控制,疼痛消失。术后3-5周角膜溃疡愈合,12眼视力不同程度提高。1眼复发,1眼早期羊膜溶解。结论 新鲜羊膜移植是治疗角膜溃疡的有效方法。
Objective To investigate the feasibility, operation and clinical effect of fresh amniotic membrane transplantation for the treatment of corneal ulcer. Methods Fresh amniotic membrane transplantation was used to treat 16 cases of corneal ulcer, including 6 cases of bacterial corneal ulcer, 3 cases of viral corneal ulcer, 2 cases of recurrent germ-resistant corneal ulcer, 2 cases of bullous keratopathy and 3 cases of persistent corneal epithelial defect 3 eye. Surgical methods were: single-layer amniotic membrane transplantation in 6 eyes, multiple amniotic membrane transplantation in 7 eyes, amniotic membrane transplantation combined with active limbal lamellar keratoplasty in 3 eyes. Postoperative follow-up 6-19 months. Results No acute rejection of fresh amnion graft was found after operation, and 14 eyes were cured in 16 eyes. 3-15 days after surgery, inflammation control, pain disappeared. Corneal ulcer healed 3-5 weeks after operation, and 12 eyes improved in varying degrees. 1 eye recurrence, 1 eye early amniotic lysis. Conclusion Fresh amniotic membrane transplantation is an effective method for the treatment of corneal ulcer.