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目的：了解细胞外基质在肝细胞癌的分布形式，探讨其与肝细胞癌恶性程度的关系。方法：用５种细胞外基质抗体对４０例肝细胞癌作免疫组化染色。结果：显示４种分布形式：连续梁周腺泡周型、断续梁周腺泡周型、血管间质型、胞膜胞浆型。前３型与肿瘤生长方式、细胞分化和增殖程度密切相关。结论：提示细胞外基质在评价肝细胞癌的恶性程度是有用的标志物。
Objective: To understand the distribution of extracellular matrix in hepatocellular carcinoma and to explore its relationship with the degree of malignancy of hepatocellular carcinoma. Methods: Immunohistochemical staining of 40 cases of hepatocellular carcinoma with 5 extracellular matrix antibodies. RESULTS: Four types of distributions were shown: continuous girdle perianal, intermittent girdle perianal, vascular interstitial and cytoplasmic cytoplasmic. The first 3 types are closely related to the tumor growth pattern, cell differentiation and proliferation. Conclusion: It is suggested that extracellular matrix is a useful marker for evaluating the degree of malignancy of hepatocellular carcinoma.