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作者分析了16例急性淋巴细胞性白血病(ALL)患者的核型。患者中成人(18—51岁)10例,小孩(3—15岁)6例。作第一次细胞遗传学研究时,其疾病都在活动。12例的核型分析是在治疗前作的。16例中仅1例是复发的,其余都是新诊断出来的患者。初诊时核型正常者8例,其中3例后来复发时有核型演变。8例最初分析核型异常者中有2例随疾病的发展染色体异常有增加。分析核型前未经治疗的12例患者中,5例最初核型正常,7例异常。曾接受过治疗的4例患者中,3例核型正常,1例异常。
The authors analyzed karyotypes in 16 patients with acute lymphoblastic leukemia (ALL). Among the patients, 10 were adults (18-51 years) and 6 were children (3-15 years). The first cytogenetic study, the disease is active. Karyotype analysis of 12 patients was done before treatment. Only 1 of 16 cases was recurrent, and the rest were newly diagnosed. The first visit of normal karyotype in 8 cases, of which 3 cases later recurrence karyotype evolution. Of the 8 patients initially diagnosed with karyotypic abnormalities, 2 had an increased chromosomal abnormality with the development of the disease. Of the 12 untreated karyotypes, 5 were initially normal and 7 were abnormal. Of the 4 patients who received treatment, 3 had normal karyotypes and 1 had abnormalities.