论文部分内容阅读
目的 :观察慢性低氧及低氧游泳大鼠心肌糖原含量的变化 ,探讨其与右心舒缩功能升降的关系。方法 :采用低压舱模拟海拔 5 0 0 0m连续低氧及低氧游泳大鼠模型 ,用比色法测定其心肌糖原含量 ;用右心导管法经RM - 6 0 0 0生理多导记录仪记录右心舒缩功能指标。结果 :大鼠心肌糖原含量在低氧早期即显著下降 ,随低氧时间的延长 ,呈较明显进一步下降的趋势 ,而右心功能则逐渐增强 ;低氧游泳组大鼠右心功能明显增强 ,其心肌糖原含量接近平原对照水平 ,显著高于单纯低氧组。结论 :大鼠在低氧条件下适量作功 (游泳 ) ,可能有利于机体的低氧适应。
Objective: To observe the changes of myocardial glycogen in rats with chronic hypoxia and hypoxia, and to explore the relationship between the changes of right ventricular systolic and diastolic function. Methods: The model of hypoxia and hypoxia swimming at altitudes of 500 m was simulated by low-pressure cabin and the content of cardiac glycogen was measured by colorimetric method. The right cardiac catheterization was performed by RM-600 physiological multi-recorder Record right heart systolic function index. Results: The content of myocardial glycogen decreased significantly in early hypoxia, decreased further with the prolongation of hypoxia, and gradually increased in right heart. The function of right heart in hypoxic swimming group increased significantly , Its myocardial glycogen content close to the level of plain control, significantly higher than the simple hypoxic group. CONCLUSIONS: Appropriate amount of exercise (swimming) in rats under hypoxic conditions may be beneficial to the body’s hypoxic adaptation.