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目的大样本分析广东省珠三角地区5年中地诺前列酮栓用于孕晚期引产的临床疗效和安全性。方法将广东省珠三角地区使用地诺前列酮栓进行孕晚期引产的20家医院按医院级别分层,省级医院和市区级医院各选取三家医院作为研究单位。按照严格的纳入标准和剔除标准筛选出6家医院2010年1月~2014年12月1390例地诺前列酮栓引产病例作为研究组,并抽取同期957例单纯使用缩宫素引产病例作为对照组,回顾性分析地诺前列酮栓的临床疗效及安全性。结果地诺前列酮栓组的第1产程潜伏期时长为4.06±2.65 h,长于缩宫素组3.20±2.08 h,2组相比结果有统计学意义[P=0.003,95%CI(0.182,0.920)],地诺前列酮栓组活跃期及第2产程时长为1.73±1.32 h/0.49±0.37 h,短于缩宫素组2.22±1.75 h/0.54±0.43 h,两组相比结果有统计学意义[P=0.000,95%CI(-0.795,-0.363)/P=0.003,95%CI(-0.137,-0.028)],两组相比第1产程及总产程无统计学差异;两组经阴道分娩率无统计学差异;母婴不良反应发生率无统计学差异。结论孕晚期地诺前列酮栓引产的安全性与缩宫素相似,临床疗效优于缩宫素,是一种安全有效的引产方法。
Objective To analyze the clinical efficacy and safety of dinoprostone suppositories for induction of labor during the third trimester of pregnancy in the Pearl River Delta of Guangdong Province. Methods 20 hospitals using droperidol suppository to induce labor in the third trimester of pregnancy in Guangdong Province were stratified by hospital level, and three hospitals at provincial and municipal level were selected as research units. According to the strict inclusion criteria and exclusion criteria, 1390 cases of denominopromycin-induced labor in 6 hospitals from January 2010 to December 2014 were screened out as the research group, and 957 cases of simple oxytocin-induced labor induced during the same period were selected as the control group , Retrospective analysis of dinoprostone suppository clinical efficacy and safety. Results The length of the first stage of labor in the nobelprost suppository group was 4.06 ± 2.65 h which was longer than that of the oxytocin group (3.20 ± 2.08 h) (P = 0.003, 95% CI 0.182, 0.920 )]. The duration of active phase and the second stage of labor of dioxinopron suppository was 1.73 ± 1.32 h / 0.49 ± 0.37 h, shorter than that of oxytocin group (2.22 ± 1.75 h / 0.54 ± 0.43 h) (P = 0.000,95% CI -0.795, -0.363) /P=0.003, 95% CI (-0.137, -0.028)]. There was no significant difference between the two groups in the first stage of labor and the total stage of labor; two Group vaginal delivery rate was no significant difference; maternal and child adverse reactions no significant difference in the incidence. Conclusion The promise of droperidol suppository in the third trimester of pregnancy is similar to that of oxytocin. The clinical effect is better than that of oxytocin, which is a safe and effective method of induction of labor.