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目的:了解广西巴马地区人群热休克蛋白70(HSP70)的血清表达水平,探讨其与长寿现象的相关性。方法:巴马地区人群为长寿组(126例),非巴马地区人群为对照组(160例)。流行病学调查了解一般状况,排除干扰因素,ELISA检测两组人群血清中HSP70的表达水平。结果:巴马地区人群血清中HSP70表达水平高于对照组,两组差异有统计学意义(P<0.05)。单因素分析显示,长寿组血清中HSP70与年龄、总胆固醇、低密度脂蛋白相关(P<0.05);多因素回归分析显示,长寿组血清中HSP70与年龄、血糖相关(P<0.05)。结论:HSP70血清表达水平与巴马长寿现象存在有一定的联系。
Objective: To understand the serum levels of heat shock protein 70 (HSP70) in the population of Bama in Guangxi and to explore its relationship with longevity. Methods: The population of Bama region was longevity group (126 cases) and the non-Bama region was control group (160 cases). Epidemiological survey to understand the general situation, excluding interference factors, ELISA detection of serum HSP70 levels in two groups of people. Results: The HSP70 expression in serum of the population of Bama was higher than that of the control group, the difference was statistically significant (P <0.05). Univariate analysis showed that serum HSP70 in longevity group was associated with age, total cholesterol and low density lipoprotein (P <0.05). Multivariate regression analysis showed that serum HSP70 in longevity group was correlated with age and blood glucose (P <0.05). Conclusion: There is a certain relationship between the expression level of HSP70 and the longevity of Bama.