以家兔颅顶骨直径１０ｍｍ园形骨缺损作为动物模型，分别植入同种（兔）、异种（人、猪、羊）的骨基质明胶。植入后４、８、１２、１６ｗ进行ｘ线摄片和组织学检查。结果显示，同种骨基质明胶无免疫排斥反应，具有良好的骨诱导作用，术后１２ｗ骨缺损完全修复；异种骨基质明胶植入早期，存在着不同程度的排斥反应，植骨后期（１２～１６ｗ），随着排斥反应的减轻，亦出现了诱导成骨。结果说明，如能改进异种骨基质明胶的制作方法，降低其抗原性，将具有重要的临床应用价值。 Rabbit skullcap 10 mm in diameter was used as the animal model for the implantation of bone matrix gelatin of the same species (rabbit, xenograft, pig, sheep). 4,8,12,16w after implantation for x-ray and histological examination. The results showed that allogeneic bone matrix gelatin did not have immune rejection and had good osteoinductive effect. The defect of bone was completely repaired at 12w after operation. In the early stage of xenograft gelatin, there were different degrees of rejection. 16w), with the rejection of the reduction, but also appeared to induce osteogenesis. The results show that if we can improve the production of xenograft matrix gelatin and reduce its antigenicity, will have important clinical value.