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血管性血友病因子 (ｖＷＦ)是体内参与止、凝血功能的多聚体糖蛋白[1,2 ] ,在血栓形成中起着关键性作用[3 ] 。ｖＷＦ多肽序列中Ｔｈｒ789Ａｌａ多态性也是Ｉ型糖尿病病人中冠心病发生的一个危险因素[4 ] 。ＳｍａＩ多态性位于ｖＷＦ基因第 2内含子中[1] ,本研究的目的就是探讨
Von Willebrand factor (vWF) is a multimeric glycoprotein involved in coagulation in the body [1,2] and plays a pivotal role in thrombosis [3]. Thr789Ala polymorphism in the vWF polypeptide sequence is also a risk factor for coronary heart disease in type I diabetic patients [4]. SmaI polymorphism is located in the second intron of vWF gene [1], the purpose of this study is to explore