本研究以Harris法对辛硫磷与甲基对硫磷、灭多威以及3种拟除虫菊酯以等毒剂量混配时对大鼠急性经口毒性联合作用的性质进行了评价。结果表明 ,辛硫磷与甲基对硫磷混配为拮抗作用 ;与灭多威混配为相加作用 ;辛硫磷与溴氰菊酯或高效氯氰菊酯混配时毒性分别增加4～6倍多 ,呈协同作用 ;与氰戊菊酯混配虽属相加作用但毒性有较大增加 ,为预期毒性的1.5倍。本研究表明辛硫磷与有机磷或氨基甲酸酯混配可出现相加或拮抗作用 ,而与拟除虫菊酯混配则毒性增加 ,常呈协同作用。作者对所发生联合作用的性质从毒代动力学、毒效动力学和所涉及的生化机制进行了讨论 In this study, Harris’s method was used to evaluate the acute oral toxicity of phoxim and methyl parathion, methomyl and three pyrethroids in rats. The results showed that the combination of phoxim and parathion-methyl was antagonistic; the combination with methomyl was additive; the toxicity of phoxim combined with deltamethrin or beta-cypermethrin increased by 4 ~ 6 times More, was a synergistic effect; Although mixed with fenvalerate but an additive effect but a greater increase in toxicity, 1.5 times the expected toxicity. This study shows that phoxim may be additive or antagonistic when mixed with organophosphorus or carbamate, whereas toxicity with pyrethroids may increase with synergistic effects. The authors discuss the nature of the combined effects from toxicokinetics, toxicodynamic effects and the biochemical mechanisms involved