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目的观察泮托拉唑与奥美拉唑治疗十二指肠溃疡的临床效果,总结经验以提高治疗水平。方法将2009年2月~2013年2月河南省驻马店市新蔡县人民医院内科收治的110例十二指肠溃疡患者随机分为观察组与对照组,观察组患者应用泮托拉唑治疗,对照组患者应用奥美拉唑治疗,比较2组治疗效果。结果观察组腹痛消失时间平均为(2.75±1.16)d,对照组腹痛消失时间(3.82±1.42)d,两者相比差异具有统计学意义(P<0.05)。观察组总有效率96.4%;对照组总有效率92.7%。两者治疗效果相比差异无统计学意义。结论泮托拉唑与奥美拉唑治疗十二指肠溃疡疗效均较为理想,但泮托拉唑缓解腹痛较奥美拉唑更为迅速,具有更高的临床推广价值。
Objective To observe the clinical effects of pantoprazole and omeprazole in the treatment of duodenal ulcer and to summarize the experience to improve the treatment level. Methods A total of 110 patients with duodenal ulcer admitted to Xincai County People’s Hospital of Zhumadian City, Henan Province from February 2009 to February 2013 were randomly divided into observation group and control group. The patients in observation group were treated with pantoprazole, The patients in the control group were treated with omeprazole, and the treatment effect was compared between the two groups. Results The average disappearance time of abdominal pain in observation group was (2.75 ± 1.16) d, and the disappearance time of abdominal pain in control group (3.82 ± 1.42) d, the difference was statistically significant (P <0.05). The total effective rate was 96.4% in observation group and 92.7% in control group. No significant difference between the two treatment effects. Conclusions The efficacy of pantoprazole and omeprazole in the treatment of duodenal ulcer are ideal, but the pantoprazole to relieve abdominal pain is more rapid than omeprazole, and has a higher clinical value.