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为观察胃食管反流病(GERD)的临床表现及治疗反应,对67例经24h食管内pH监测确诊的GERD病人进行观察和分析,结果胸痛37例(55.2％)、咽部异物感33例(49.3％)、胸闷25例(37.3％)、呛咳10例(14.9％)、哮喘2例(3.0％),内镜发现食管炎45例,食管粘膜正常22例,测压显示食管下括约肌静息压(LESP)低于正常22例,其余患者压力均正常或偏高。用奥美拉唑治疗,起效时间平均2±1天,而用H_2受体阻滞剂治疗起效时间平均7±2天(P<0.01)。提示GERD并不罕见,个别病人临床表现特殊,其食管粘膜在内镜下可完全正常,仅1/3病人表现为LESP低下,加用西沙比利时,泵抑制剂的疗效优于H_2受体阻滞剂。
To observe the clinical manifestation and treatment response of gastroesophageal reflux disease (GERD), 67 cases of GERD patients diagnosed by 24h intra-esophageal pH monitoring were observed and analyzed. RESULTS: Thirty-seven cases (55.2%) had chest pain and 33 cases had pharyngeal foreign body sensation (49.3%), 25 cases of chest tightness (37.3%), 10 cases of cough (14.9%), 2 cases of asthma (3.0%), 45 cases of endoscopic esophagitis and 22 cases of normal esophageal mucosa. Resting pressure (LESP) was lower than the normal in 22 cases, the rest of the patients were normal or high pressure. With omeprazole treatment, the onset time of an average of 2 ± 1 days, while with H_2 receptor blocker treatment onset time of an average of 7 ± 2 days (P <0.01). This suggests that GERD is not uncommon. The clinical manifestations of individual patients are very special. The esophageal mucosa of the esophageal mucosa can be completely normal under endoscopy. Only 1/3 of the patients showed low LESP. The effect of pump inhibitor over H_2 receptor blockade Agent.