本工作用二种十八烷基键合相的反相色谱系统测定了36个不同极性的取代苯胺甲酰甲基亚氨二乙酸类化合物的logk′值,回归分析表明:间、对位化合物的logk′值与它们的理论疏水性∑π值之间具有很好的线性相关,邻位取代会降低配体化合物的logk′值,而分子内氢键会增大配体化合物的logk′值。上述配体化合物的logk′与它的标记物在肝胆和小肠中的浓 In this work, the logk ’values ​​of 36 substituted phenylcarbamoylaminodiacetic acids with different polarities were determined by reversed-phase chromatography with two octadecyl-bonded phases. The regression analysis showed that: There is a good linear correlation between the logk ’values ​​of the compounds and their theoretical hydrophobic ΣΣ values. Ortho substitution reduces the logk’ values ​​of the ligand compounds, and intramolecular hydrogen bonds increase the logk ’ value. The logk of the above-described ligand compound is enriched in its hepatobiliary and small intestine with its label