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目的 探讨老年人糖耐量减退 (IGT)的痛风患者胰岛素抵抗指数的变化。方法 对 2 2例IGT的痛风患者和 1 7例IGT的无痛风患者测定空腹血糖、口服葡萄糖耐量试验 (OGTT) 2小时血糖、胰岛素及血脂、血尿酸 ,计算胰岛素抵抗指数。结果 空腹及OGTT 2小时胰岛素、胰岛素抵抗指数 ,IGT痛风组分别为(1 4 .6 6± 3.1 8)mU/L、(83.95± 2 3.2 9)mU/L、1 .4 33± 0 .2 39,IGT无痛风组分别为 (1 1 .1 1± 3.0 5 )mU/L、(6 9.2 8±2 3.5 9)mU/L、1 .1 32± 0 .2 86 ,两组比较有显著性差异 (P <0 .0 5～ 0 .0 1 ) ,且IGT痛风组甘油三酯、血尿酸升高。结论老年IGT的痛风患者较IGT无痛风患者存在明显高胰岛素血症和胰岛素抵抗。
Objective To investigate the changes of insulin resistance index in elderly patients with impaired glucose tolerance (IGT). Methods Fasting blood glucose, oral glucose tolerance test (OGTT) 2 hours blood glucose, insulin, blood lipid and serum uric acid were measured in 22 gout patients with IGT and 17 gout patients with IGT. The index of insulin resistance was calculated. Results Fasting and 2-hour OGTT insulin resistance index, IGT gout group were (14.66 ± 3.1 8) mU / L, (83.95 ± 2 3.2 9) mU / L and 1.333 ± 0.2 39, IGT gout group were (11.1 ± 3.05) mU / L, (6 9.28 ± 2 3.59) mU / L and 1.12 ± 0.226, respectively, with significant difference between the two groups (P <0.05-0.01), and triglycerides and serum uric acid increased in gout group. Conclusions Gout patients with IGT in the elderly have significantly hyperinsulinemia and insulin resistance compared with IGT patients without gout.