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目的:观察氯沙坦与非洛地平联合用药治疗高血压合并慢性肾衰竭的效果。方法:选择75例老年患者,随机分为治疗组和对高血压合并慢性肾衰竭照组,治疗组给予氯沙坦50 mg.d-1,非洛地平10 mg.d-1,对照组给予硝苯地平控释片20mg,bid,8周为一疗程。观察治疗前后血压、24 h尿蛋白、血肌酐(Cr)、尿素氮(BUN)的水平。结果:2组治疗后血压均有显著下降(P<0.05),2组之间比较差异无显著性(P>0.05);2组治疗后24 h尿蛋白含量显著降低(P<0.01或P<0.05),2组之间比较差异显著(P<0.01);治疗组治疗后Cr、BUN明显降低(P<0.05),对照组无明显变化(P>0.05),2组之间比较差异显著(P<0.01)。结论:氯沙坦与非洛地平在降压的同时对老年人高血压合并慢性肾衰竭患者肾功能有明显保护作用。
Objective: To observe the effect of losartan combined with felodipine in the treatment of hypertension and chronic renal failure. Methods: Seventy-five elderly patients were randomly divided into treatment group and chronic renal failure group with hypertension. Losartan 50 mg.d-1 and felodipine 10 mg.d-1 were given to the treatment group and control group Nifedipine controlled release tablets 20mg, bid, 8 weeks for a course of treatment. Blood pressure, 24h urinary protein, serum creatinine (Cr) and blood urea nitrogen (BUN) were observed before and after treatment. Results: After treatment, blood pressure decreased significantly in both groups (P <0.05), but there was no significant difference between the two groups (P> 0.05). Urine protein content in two groups decreased significantly at 24 hours after treatment (P <0.01 or P < 0.05). There was significant difference between the two groups (P <0.01). Cr and BUN in the treatment group were significantly decreased (P <0.05), but there was no significant change in the control group (P> 0.05) P <0.01). Conclusion: Losartan and felodipine have a significant protective effect on the renal function in elderly patients with hypertension and chronic renal failure.