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[目的]探讨老年骨质疏松患者瘦素(leptin)、肿瘤坏死因子α(TNF-α)、白介素-2(IL-2)、胰岛素样生长因子1(IGF-1)水平的变化及其临床意义。[方法]选择2010~2014年驻地干休所老年患者80例,根据骨质疏松诊断标准分为骨质疏松组(osteoporosis group,35例)和骨量减少组(osteopenia group,45例),并选择同期老年体检患者30例为对照组。检测外周血血清Leptin、TNF-α、IL-2、IGF-1水平,并测定骨密度。[结果]骨质疏松组及骨量减少组血清IL-2和IGF-1水平均明显低于对照组(P<0.05),血清Leptin和TNF-α水平明显高于对照组(P<0.05);骨质疏松组与骨量减少组骨密度均明显低于对照组(P<0.05),同时骨质疏松组骨密度也明显低于骨量减少组(P<0.05);血清中IL-2和IGF-1水平与骨密度值均呈正相关(r=0.35,0.39,P<0.05),而Leptin、TNF-α与骨密度值呈负相关(r=-0.35,P<0.05)。[结论]Leptin、TNF-α、IL-2及IGF-1对辅助诊断和治疗老年骨质疏松症有一定的临床意义。
[Objective] To investigate the changes of leptin, tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2) and insulin-like growth factor 1 (IGF-1) in elderly patients with osteoporosis significance. [Methods] Eighty elderly patients in the dry-rest hospital from 2010 to 2014 were divided into osteoporosis group (35 cases) and osteopenia group (45 cases) according to the diagnostic criteria of osteoporosis Select the same period of 30 elderly patients in the control group. Peripheral blood serum Leptin, TNF-α, IL-2, IGF-1 levels were measured and bone mineral density was measured. [Results] The levels of serum IL-2 and IGF-1 in osteoporosis group and osteopenia group were significantly lower than those in control group (P <0.05), and the levels of serum Leptin and TNF-α in serum were significantly higher than those in control group (P <0.05) (P <0.05). The bone mineral density in osteoporosis group and osteopenia group were also significantly lower than those in control group (P <0.05) (R = 0.35,0.39, P <0.05), but there was a negative correlation between Leptin and TNF-α and bone mineral density (r = -0.35, P <0.05). [Conclusion] Leptin, TNF-α, IL-2 and IGF-1 have some clinical significance in the diagnosis and treatment of senile osteoporosis.