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目的:探讨马齿苋水煎剂对糖尿病胃轻瘫大鼠糖化血红蛋白(HbA1c)、胃动素(MTL)的影响。方法:一次性腹腔注射链脲佐菌素并给予高脂高糖不规则饮食喂养8周制备糖尿病胃轻瘫模型;分别予马齿苋水煎剂大、中、小剂量干预,并设吗丁啉对照组。给药8周,检测血清HbA1C、血浆MTL含量。结果:马齿苋水煎剂能降低糖尿病胃轻瘫大鼠血清HbA1C、血浆MTL的含量,且有剂量依存性。结论:马齿苋水煎剂具有治疗糖尿病胃轻瘫大鼠胃动力减慢的作用。
Objective: To investigate the effects of purslane decoction on glycated hemoglobin (HbA1c), motilin (MTL) in diabetic gastroparesis rats. Methods: One-time intraperitoneal injection of streptozotocin and given high-fat, high-sugar, irregular diet for 8 weeks to prepare diabetic gastroparesis model; respectively, purslane decoction of large, medium and small doses of intervention, Control group. Administered for 8 weeks, serum HbA1C, plasma MTL content. Results: Purslane decoction can reduce the content of serum HbA1C and plasma MTL in diabetic gastroparesis rats, and dose-dependent. Conclusion: The purslane decoction has the effect of slowing gastric motility in rats with diabetic gastroparesis.