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自从1953年首次报导大量服用含非那西汀(phenacetin)的镇痛剂引起肾脏损害以来,迄今已有2、3千这种病例报告。本文报导南非某一医院于1963年1月至1970年12月期间收治的940例肾脏疾病患者中,本病占66例(7％)。服用镇痛剂最常见的原因是严重头痛(特别是偏头痛)有48例(73％),其他尚有背痛4例,副鼻窦炎3例,关节痛3例。本病的主要诊断标准为:(1) 病史:除2例外,所有病例均有长期大量服用镇痛剂(非那西汀)史。(2) 放射学:有肾盏呈杵状伴有“晕轮征”或肾盂肾盏充盈缺损等肾乳突坏死征象。(3) 组织学:有27例经肾活检、肾切除术,或尸检材料或脱落乳突的组织学检查证实。
Since the first reported extensive use of phenacetin-containing analgesics in 1953 to cause kidney damage, 2,3,000 such cases have been reported to date. This article reports 66 cases (7%) of 940 cases of kidney disease admitted to a hospital in South Africa from January 1963 to December 1970. The most common cause of taking painkillers was severe headache (especially migraine) in 48 cases (73%), others were backache in 4 cases, 3 cases of sinusitis, joint pain in 3 cases. The main diagnostic criteria for this disease are: (1) Medical history: All patients except for 2 had long history of extensive use of analgesics (phenacetin). (2) Radiology: there is a calyceal clubbing was accompanied by “halo sign” or renal pelvis calyceal filling defects such as renal mastoid necrosis signs. (3) Histology: Twenty-seven cases were confirmed by histological examination of renal biopsy, nephrectomy, or autopsy material or shed papilla.