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目的:建立免疫性血小板减少性紫癜(ITP)病证结合肾阴虚小鼠模型。方法:将 ITP BALB/c 小鼠疾病模型与口服甲状腺素片肾阴虚模型进行融合。结果:该模型除具有血小板减少、骨髓巨核细胞增多等 ITP 疾病模型特点外,还具有血清三碘甲状腺原氨酸(T_3)增高,促甲状腺素激素(TSH)降低,睾酮、皮质醇、雌二醇、环磷酸腺苷(cAMP)水平升高,饮水进食量增多,体重下降,体温升高等肾阴虚模型特点,滋肾阴方改善上述主要指标的异常,而助肾阳方反之。结论:ITP 病证结合肾阴虚小鼠模型造模方法简便,指标可靠,可为中医药临床基础研究提供有用工具。
Objective: To establish a model of immune deficiency thrombocytopenic purpura (ITP) combined with kidney yin deficiency mice model. Methods: ITP BALB / c mice model of disease and oral thyroxine tablets kidney yin deficiency model fusion. Results: In addition to the features of ITP disease model such as thrombocytopenia and increase of bone marrow megakaryocytes, this model also has the features of increased serum triiodothyronine (T_3), reduced thyrotropin (TSH), testosterone, cortisol, Alcohol, cAMP levels, increased drinking water intake, weight loss, body temperature and other characteristics of the kidney yin deficiency, nourishing yin Fang to improve the above-mentioned indicators of the main anomaly, while the kidney Yang on the contrary. Conclusion: The method of modeling ITP combined with deficiency of kidney-yin deficiency mice model is simple and reliable, which can provide useful tools for clinical basic research of traditional Chinese medicine.