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30只家兔喂饲高脂饮食,四周后血脂达一定高度,其中,25只随机分成对照组、安妥明组和益气活血组。对照组续继饲胆固醇,安妥明组和益气活血组在继饲胆固醇的同时分别给予安妥明、益气活血中药煎剂灌服。本实验采用的造型方法,家兔出现少食,稀便,皮毛欠光泽,少动表现及红细胞变形能力下降,笔者认为气虚血淤模型塑造是成立的。实验结果证明了益气活血药能明显地改善症状,抑制动脉粥样硬化斑块的形成,为今后深入进行动脉粥样硬化动物模型证型的研究打下良好的基础。
Thirty rabbits were fed a high-fat diet and blood lipids reached a certain height four weeks later. Among them, 25 were randomly divided into control group, Antuo Ming group and Yiqi Huoxue group. The control group continued to feed cholesterol, and the Antuo Ming group and the Yiqi Huoxue group were fed with Anbumin and Yiqihuoxue decoction respectively after feeding cholesterol. In the modeling method used in this experiment, rabbits appeared to eat less, loose stools, and lacked luster in fur, less dynamic performance and decreased red blood cell deformability. The author believes that the model of qi deficiency and blood stasis is established. The experimental results prove that Yiqihuoxue can obviously improve the symptoms and inhibit the formation of atherosclerotic plaque, which lays a good foundation for further research on the animal model of atherosclerosis.