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蛋白酶及其抑制剂是非常重要的信号分子,涉及多个关键的人体生理代谢途径,在体内受到严格的调控.蛋白酶抑制剂活性的紊乱可导致多种疾病,诸如心血管和炎症疾病、癌症和神经系统障碍等.已知蛋白酶在肿瘤细胞侵袭和转移过程中扮演着重要的角色.细胞外基质和基底膜重塑是癌细胞侵袭转移过程中的关键环节,这个过程需多个蛋白水解酶的表达和激活.蛋白酶抑制剂的应用在一定程度上可减少由蛋白酶水解引起的肿瘤细胞的侵袭和转移,且它的抑制作用具有不同程度的特异性,可以减缓肿瘤恶性发展的进程.文章对蛋白酶及其抑制剂的靶向治疗药物及临床应用研究进展进行了综述.
Proteases and their inhibitors are very important signaling molecules involved in a number of key human physiological metabolic pathways that are tightly regulated in the body.Disorders of protease inhibitor activity can lead to a variety of diseases such as cardiovascular and inflammatory diseases, cancer and Nervous system disorders, etc. Proteases are known to play an important role in the invasion and metastasis of tumor cells.Cell remodeling of extracellular matrix and basement membrane is a key step in the invasion and metastasis of cancer cells, which requires multiple proteolytic enzymes Expression and activation.The application of protease inhibitors to a certain extent can reduce the invasion and metastasis of tumor cells caused by protease hydrolysis, and its inhibition has varying degrees of specificity, can slow the process of tumor malignant development.In this paper, protease And its inhibitors of targeted therapies and clinical application of research progress are reviewed.