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目的：观察口服米非司酮合并米索前列醇终止１０～１６ｗｋ妊娠的临床疗效。方法：１７５例妊娠１０～１６ｗｋ妇女用２种不同剂量米非司酮（组Ⅰ２５ｍｇｂｉｄ×３ｄ，总量１５０ｍｇ；组Ⅱ２００ｍｇ单次用药），合并米索前列醇（最大剂量不超过１．６ｍｇ）口服。结果：２组流产成功率分别为８９％和８４％，Ｐ＞０．０５。组Ⅰ胎儿排出时间（７ｈ）明显短于组Ⅱ（９ｈ），Ｐ＜０．０１。组Ⅰ米索前列醇用量（０．７ｍｇ）明显少于组Ⅱ（１．０ｍｇ），Ｐ＜０．０１。结论：口服米非司酮合并米索前列醇终止１０～１６ｗｋ妊娠是安全有效的；给药方法以米非司酮小剂量多次给药法更可取。
Objective: To observe the clinical efficacy of oral mifepristone combined with misoprostol to terminate 10 ~ 16wk pregnancy. METHODS: One hundred and seventy women with pregnancy between 10 and 16 weeks were treated orally with two different doses of mifepristone (group I, 25mgbid × 3d, total 150mg; group Ⅱ, 200mg single) with misoprostol (maximal dose not exceeding 1.6 mg) . Results: The success rates of abortion in two groups were 89% and 84%, respectively, P> 0.05. Group Ⅰ fetal discharge time (7h) was significantly shorter than group Ⅱ (9h), P <0.01. The amount of misoprostol in group I (0.7 mg) was significantly less than that in group II (1.0 mg), P <0.01. Conclusion: Mifepristone combined with misoprostol to terminate 10 ~ 16wk pregnancy is safe and effective. The administration method of mifepristone in small dose multiple administration is preferable.