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目的观察牛黄熄风胶囊（ＮＨＸＦＣ）对实验性急性脑梗塞大鼠的疗效，初步研究其作用机理。方法３０只Ｗｉｓｔａｒ脑梗塞大鼠随机分为３组，分别以牛黄熄风胶囊、莶通栓丸（ＸＱＴＳＰ）和生理盐水灌胃治疗７ｄ，治疗前后检查神经病学评分和病理组织学改变。结果牛黄熄风胶囊组治疗后的神经病学评分明显低于治疗前和生理盐水对照组（Ｐ＜０．０１），但与ＸＱＴＳＰ组间差异无显著性（Ｐ＞０．０５），病理显示：治疗后牛黄熄风胶囊组脑神经细胞的损害明显改善。结论牛黄熄风胶囊有及早促进脑血管再通，改善缺血，减轻脑细胞损害，对缺血性脑损伤具有保护作用。
Objective To observe the curative effect of Niuhuang Xifeng Capsule (NHXFC) on experimental acute cerebral infarction rats and to study its mechanism. Methods Thirty Wistar rats with cerebral infarction were randomly divided into 3 groups. The rats were treated with bezoar Xifeng capsule, XQTSP and saline for 7 days respectively. The neurological scores and histopathological changes were observed before and after treatment. Results Neurological score of Bezoar Xifeng capsule group was significantly lower than that before treatment and saline control group (P <0.01), but no significant difference with XQTSP group (P> 0.05) After treatment, bezoar Xifeng Capsule group, the damage of brain nerve cells was significantly improved. Conclusion Niuhuang Xifeng Capsule can promote cerebrovascular recanalization as soon as possible, improve ischemia, alleviate the damage of brain cells and protect the ischemic brain injury.