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目的:观察云艾散对大鼠胃溃疡愈合的影响作用。方法:健康SD大鼠20只,设正常对照组5只,其余15只复制乙酸性胃溃疡模型,随机分为模型对照组、云艾散组和雷贝拉唑组,各组分别予以蒸馏水、云艾散浓缩药液0.657g/ml、雷贝拉唑混悬液0.18mg/ml各2ml/d灌胃14天,观察各组胃黏膜形态学、病理组织学及血清中表皮生长因子(EGF)、前列腺素E_2(PGE_2)、胃泌素(GAS)表达变化情况。结果:云艾散、雷贝拉唑均能抑制模型大鼠胃黏膜组织损伤,降低溃疡指数,提高溃疡抑制率;两组均能提高血清中EGF含量,抑制GAS表达,与模型对照组比较均具有显著差异(P<0.0.1和0.05);云艾散、雷贝拉唑两组间比较,无显著差异(P>0.05)。结论:云艾散能促进模型大鼠胃溃疡愈合,并能提高愈合质量,其效应与雷贝拉唑相当。
Objective: To observe the effect of Yun Ai San on the healing of gastric ulcer in rats. Methods: Twenty healthy SD rats were divided into normal control group (n = 5) and the other 15 rats were randomly divided into model control group, Yunai powder group and rabeprazole group. Each group was given distilled water, Yun Ai San concentrated liquid 0.657g / ml, rabeprazole 0.18mg / ml suspension 2ml / d gavage for 14 days, the gastric mucosa morphology, histopathology and serum epidermal growth factor (EGF ), Prostaglandin E2 (PGE2), gastrin (GAS) expression changes. Results: Yunayasan and rabeprazole could both inhibit the gastric mucosal tissue injury, reduce the ulcer index and increase the ulcer inhibition rate. Both groups could increase the content of EGF in serum and inhibit the expression of GAS, compared with the model control group There was significant difference (P <0.0.1 and 0.05). There was no significant difference between Yun Ai San and Rabeprazole (P> 0.05). Conclusion: Yun Ai San can promote the healing of gastric ulcer in model rats and improve the quality of healing with the same effect as rabeprazole.