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目的 探讨急性胰腺炎 (AP)和全身炎症反应综合征 (SIRS)的关系。方法 观察 71例AP患者的生长抑素治疗作用及重症急性胰腺炎 (SAP)进展为SIRS的过程。结果 多数SAP患者 (86 % )可以出现SIRS ,而轻型急性胰腺炎患者中出现SIRS甚少 (11% ) ;SAP患者血清IL - 1β、TNFα和IL - 6水平明显升高 ,并与SAP的病损程度及SIRS的表现呈正相关。结论 SAP患者可以出现SIRS ,生长抑素对SAP的SIRS防治有积极作用。
Objective To investigate the relationship between acute pancreatitis (AP) and systemic inflammatory response syndrome (SIRS). Methods The somatostatin treatment in 71 AP patients and the progress of severe acute pancreatitis (SAP) to SIRS were observed. Results SIRS occurred in most SAP patients (86%), but SIRS was very low in patients with mild acute pancreatitis (11%). Serum levels of IL - 1β, TNFα and IL - 6 in patients with SAP were significantly higher than those in patients with SAP Loss levels and the performance of SIRS were positively correlated. Conclusion SIRS may occur in SAP patients and somatostatin may have a positive effect on SIRS prevention and treatment in SAP patients.