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提出了一种毛细管电泳化学发光联用技术同时测定氯丙嗪和异丙嗪。在酸性条件下,氯丙嗪和异丙嗪能被Ce(Ⅳ)氧化,然后将能量转移给荧光发射体-罗丹明6G,并以化学发光形式释放能量。基于此,结合流动注射技术,以10 mmol/L KH2PO4/H3PO4(pH3.5)为运行缓冲液,实现了两种药物的分离。方法的线性范围分别为4.0×10-8~2.0×10-6g/mL和2.0×10-8~2.0×10-6g/mL,检出限分别为5.6 ng/mL和3.4 ng/mL,对2.0×10-6g/mL异丙嗪平行测定了9次,相对标准偏差为2.8%。方法可用于同时测定人血清中的氯丙嗪和异丙嗪。
A capillary electrophoresis chemiluminescence (GPC) technique was proposed for the simultaneous determination of chlorpromazine and promethazine. Under acidic conditions, chlorpromazine and promethazine can be oxidized by Ce (IV), then the energy is transferred to the fluorescent emitter - rhodamine 6G, and the energy is released in the form of chemiluminescence. Based on this, in combination with flow injection, the separation of the two drugs was achieved using 10 mmol / L KH2PO4 / H3PO4 (pH3.5) as the running buffer. The linear range of the method was 4.0 × 10-8 ~ 2.0 × 10-6g / mL and 2.0 × 10-8 ~ 2.0 × 10-6g / mL with the detection limits of 5.6 ng / mL and 3.4 ng / mL, respectively. 2.0 × 10-6g / mL promethazine was tested in parallel for 9 times with a relative standard deviation of 2.8%. The method can be used for simultaneous determination of chlorpromazine and promethazine in human serum.