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Org2766是ACTH_(4-9)片段的类似物,不具有促皮质激素活性,而有中枢作用。近年来报道这种神经活性肽能改善外周或中枢神经实验性损伤所致的机能障碍。山莨菪碱能改善微循环,并可能对细胞有保护作用。我们新近研究亦表明Org2766和山莨菪碱(654-2)能减轻大鼠额叶皮层损伤所致学习记忆障碍。本实验探讨在同样给药方法和行为实验条件下,这两种药物对正常大鼠学习记忆的影响。
Org2766 is an analogue of the ACTH 4-9 fragment that has no central corticosteroid activity. It has been reported in recent years that this neuropeptide can improve dysfunction caused by experimental damage of peripheral or central nervous system. Anisodamine improves microcirculation and may have protective effects on cells. Our recent studies also showed that Org2766 and anisodamine (654-2) attenuated learning and memory impairments induced by frontal cortex injury in rats. The experiment to explore the same methods of administration and behavior of experimental conditions, the two drugs on normal rats learning and memory.