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目的ＣＤ＋４Ｔ细胞、ＣＤ－８细胞以及ＮＫ细胞杀伤活性在炎性脱鞘性神经病中的变化规律和意义。方法分离外周单核淋巴细胞，采用ＡＰＡＡＰ法研究Ｔ细胞亚群、ＬＤＨ释放试验检测ＮＫ细胞活性。结果。ＡＩＤＰ发病初期ＣＤ４＋Ｔ细胞为主．在疾病的恢复期以ＣＤ８－Ｔ细胞为主，ＮＫ细胞的活性早于Ｔ细胞亚群的改变。ＣＩＤＰ病人ＣＤ＋８Ｔ细胞远远超过ＣＤ－４Ｔ细胞，在整个临床疾病过程中ＮＫ细胞活性持续较低。结论，ＡＩＤＰ和ＣＩＤＰ存在着不同的免疫损伤机制在疾病的不同时期ＣＤ４＋Ｔ和ＣＤ８－Ｔ细胞发挥了不同的作用，ＮＫ细胞可能具有重要的调节作用。
Objective To study the regularity and significance of the changes of cytotoxic activity of CD + 4T cells, CD-8 cells and NK cells in inflammatory degenerative neuropathy. Methods Peripheral mononuclear lymphocytes were isolated and the T cell subsets were studied by APAAP method. The activity of NK cells was detected by LDH release assay. result. CD4 + T cells are predominant in the early stage of AIDP. CD8-T cells are predominant in the recovery phase of the disease, and NK cell activity precedes changes in T cell subsets. CD + 8T cells in CIDP patients far outnumber CD-4T cells and continue to have low NK cell activity throughout the course of clinical disease. Conclusions There are different mechanisms of immunological damage in AIDP and CIDP. CD4 + T and CD8-T cells play different roles at different stages of the disease, and NK cells may play an important regulatory role.