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自从Bouroncle等人在1958年首次报告了毛细胞白血病以来,此种慢性淋巴增生性疾病的临床经过及其诊断标准已进一步明确。此病最常发生于35～55岁的男性,其特征是各类血细胞减少,脾大及末梢血中的毛细胞数量变化不定。这种罕见疾病引起临床研究者注意的两个主要原因是:毛细胞稀有的特征(这些细胞的来源已引起很多争论)及观察到用两种药物[即干扰素和脱氧助间型霉素(deoxycofor-mycin)]治疗有令人满意的临床效果。毛细胞是带有突出的胞浆绒毛的白细胞,
Since Bouroncle et al. First reported hairy cell leukemia in 1958, the clinical course of this chronic lymphoproliferative disease and its diagnostic criteria have been further clarified. The most common disease occurs in men aged 35 to 55 years, characterized by various types of cytopenias, splenomegaly and peripheral blood hair cells in varying numbers. Two of the major causes of this rare disease are of clinical note to the attention of researchers: the characteristic features of hair cells that are scarce (the sources of these cells have caused much controversy) and the observation that two drugs, interferon and deoxycoformycin deoxycofor-mycin)] treatment has a satisfactory clinical effect. Hair cells are leukocytes with prominent cytoplasmic villi,