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为探讨维甲酸（ＲＡ）对兔视网膜色素上皮（ＲＰＥ）细胞增殖的影响，我们在传代培养的兔ＲＰＥ细胞中分别加入不同浓度的ＲＡ，用溴脱氧嘧啶（ＢｒｄＵ）掺入标记法测定ＤＮＡ合成，计算各药物浓度下的ＢｒｄＵ标记率。结果表明：ＲＡ能明显抑制ＲＰＥ细胞的ＤＮＡ合成（Ｐ＜００１）。这种抑制作用呈剂量依赖趋势，为ＲＡ治疗增殖性玻璃体视网膜病变（ＰＶＲ）奠定理论基础。
To investigate the effect of retinoic acid (RA) on the proliferation of retinal pigment epithelium (RPE) in rabbits, different concentrations of RA were added to the cultured RPE cells of rabbits separately. The DNA synthesis was determined by incorporation of BrdU , Calculate the BrdU labeling rate of each drug concentration. The results showed that RA could significantly inhibit the DNA synthesis of RPE cells (P <001). This inhibitory effect in a dose-dependent manner, RA for the treatment of proliferative vitreoretinopathy (PVR) laid the theoretical foundation.