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报道了23碱基组成的TGFα反义寡聚核苷酸和对照寡聚核苷酸对人膀胱移行细胞癌BIU87细胞增殖及其TGFαmRNA表达的作用,结果表明:TGFα反义寡聚核苷酸抑制体外培养的BIU87细胞的增殖、DNA合成和TGFαmRNA的表达,进一步证明了TGFα在BIU87细胞恶性增殖中的重要作用.
Reported the 23 base of TGFα antisense oligonucleotide and control oligonucleotide on human bladder transitional cell carcinoma BIU87 cell proliferation and TGFα mRNA expression results showed that: TGFα antisense oligonucleotide inhibition The proliferation, DNA synthesis and TGFα mRNA expression of BIU87 cells cultured in vitro further proved that TGFα plays an important role in the malignant proliferation of BIU87 cells.