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目的探讨不同种铁制剂对小儿缺铁性贫血的临床治疗效果及安全性。方法将该院儿童保健科收治的150例轻、中度缺铁性贫血患儿纳为研究对象,根据数字表法分为Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ5组,每组30例,分别给予硫酸亚铁、富马酸亚铁、葡萄糖酸亚铁、琥珀酸亚铁及蛋白琥珀酸铁治疗,对比各组治疗效果及不良反应。结果各组治疗后的各项指标比治疗前均明显升高(P<0.05);Ⅳ组、Ⅴ组患儿治疗后的各项指标明显高于其余3组(P<0.05);Ⅰ组不良反应发生率最高,Ⅴ组无不良反应发生,差异有统计学意义(P<0.05);其余3组均发生不同程度的不良反应。结论与其他铁剂相比,蛋白琥珀酸铁制剂治疗小儿缺铁性贫血,无论在临床效果方面还是在安全性方面均有明显优势,应重点推广使用。
Objective To investigate the clinical effects and safety of different kinds of iron preparations on iron deficiency anemia in children. Methods A total of 150 mild and moderate iron deficiency anemia children admitted to the Department of Child Health Care of the hospital were enrolled in this study. The patients were divided into Ⅰ, Ⅱ, Ⅲ, Ⅳ and Ⅴ groups according to digital table method, and each group was given 30 cases Ferrous sulfate, ferrous fumarate, ferrous gluconate, ferrous succinate and protein ferric succinate, and compared the therapeutic effects and adverse reactions in each group. Results The indexes after treatment in each group were significantly higher than those before treatment (P <0.05). The indexes in group Ⅳ and group Ⅴ were significantly higher than those in other three groups (P0.05) The highest incidence of reaction, no adverse reactions in group Ⅴ, the difference was statistically significant (P <0.05); the remaining three groups all had different degrees of adverse reactions. Conclusion Compared with other iron, iron succinate preparations for the treatment of children with iron deficiency anemia, both in terms of clinical efficacy and safety have obvious advantages, should be focused on the promotion.