目的探讨乳腺淋巴上皮瘤样癌的临床及病理形态学特点、诊断及鉴别诊断。方法应用光镜观察、免疫组化染色等方法对3例乳腺淋巴上皮瘤样癌进行分析,并复习文献。结果肿瘤组织呈结节状或弥散分布,主要由密集的成熟淋巴细胞组成,有时有纤维条索分隔;癌细胞单个或排列呈小簇状、巢状、条索状,散布于淋巴细胞中。癌细胞体积大,胞质丰富、淡染或略呈嗜酸性,圆形泡状核,核仁明显。免疫组化示癌细胞CK(+),CD30(-);病毒检测EBV与HPV均(-)。结论乳腺淋巴上皮瘤样癌是一种罕见而形态独特的乳腺癌亚型,形态与发生于其他器官的淋巴上皮瘤样癌类似,常与淋巴瘤、髓样癌等混淆;免疫组化有助于鉴别。 Objective To investigate the clinical and pathological features, diagnosis and differential diagnosis of breast lymphoepithelioma carcinoma. Methods Three cases of lymphoepithelioma carcinoma of the breast were analyzed by light microscopy and immunohistochemistry. The literature was reviewed. Results The tumor tissue was nodular or diffusely distributed, mainly composed of dense mature lymphocytes, sometimes separated by fibrous cords. The cancer cells were arranged in a single or small clusters, nests, cords and scattered in lymphocytes. Cancer cells are bulky, cytoplasm is rich, lightly stained or slightly eosinophilic, circular bubble nuclei, nucleoli obvious. Immunohistochemistry showed that the cancer cells CK (+) and CD30 (-) were positive for both EBV and HPV (-). Conclusions Breast lymphoepithelioma is a rare and unique form of breast cancer subtypes. Its morphology is similar to lymphoepithelioma-like carcinoma in other organs, often confused with lymphomas, medullary carcinomas, etc. Immunohistochemistry is helpful In the identification.