目的探讨Fisher综合征的发病机理及临床特点。方法对2004年1月至2012年3月收治的28例Fisher综合征的临床资料进行回顾性分析。结果 28例Fisher综合征24例发病前1～4周有感染史,28例表现为眼外肌麻痹、共济失调、腱反射减弱或消失,呈典型三联征表现;26例脑脊液检查有细胞蛋白分离;2例合并其他周围神经损害;22例免疫血浆免疫球蛋白升高;28例肌电图检查发现:运动及感觉神经传导速度明显减慢,F波或H反射延迟或消失;2例有呼吸肌麻痹症状;予免疫球蛋白静脉注射或血浆置换,重症可二者联合应用疗效肯定;经济条件差者可考虑应用甲强龙冲击治疗。结论Fisher综合征是以先驱感染诱导的自身免疫系统疾病,早期诊断及治疗对改善预后有益。 Objective To investigate the pathogenesis and clinical features of Fisher’s syndrome. Methods The clinical data of 28 cases of Fisher’s syndrome admitted from January 2004 to March 2012 were analyzed retrospectively. Results Twenty-four cases of Fisher’s syndrome were infected 24 weeks before the onset of infection, 28 cases showed extraocular muscle paralysis, ataxia, and tendon reflexes disappeared or disappeared, showing typical triad symptoms; 26 cases of cerebrospinal fluid were examined for cellular protein 2 cases combined with other peripheral nerve damage; 22 cases of immune plasma immunoglobulin increased; 28 cases of EMG examination: motor and sensory nerve conduction velocity slowed down, F wave or H reflex delay or disappear; 2 cases of Respiratory muscle paralysis symptoms; to immunoglobulin intravenous or plasma exchange, severe disease may be the combined effect of both positive; economic conditions may be considered to apply methylprednisolone treatment. Conclusion Fisher’s syndrome is a precursor disease induced autoimmune diseases, early diagnosis and treatment to improve the prognosis.