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采用酶联免疫吸附测定法 ,检测血浆中新型重组人肿瘤坏死因子 (rhTNF NC)的含量 ,研究rhTNF NC在小鼠体内的药代动力学 .rhTNF NCiv后 ,血药浓度时间曲线符合非线性药代动力学特征 ,t1/2 β平均为 37.4min ,3个剂量的AUC分别为 4 .0 8,10 .3和57.3mg·min·L- 1,而Cls则分别为 0 .38,0 .18和0 .0 7mL·min- 1.
The content of rhTNF NC in plasma was detected by enzyme-linked immunosorbent assay (ELISA), and the pharmacokinetics of rhTNF NC in mice was studied.After rhTNF NCiv, the time curve of plasma concentration conformed to the non-linear drug The kinetic characteristics of t1 / 2 β were 37.4 min on average, and the AUC values of the three doses were 4.08, 10.3 and 57.3 mg · min · L -1, respectively, while the Cls values were 0.38 and 0.38 respectively. 18 and 0. 0 7mL · min-1.