在许多地区甲氟喹被用来治疗或预防恶性疟,此药尤其对具有多药抗性的原虫株有效,其不良反应仅局限于肠胃道且较轻微。有些地区如泰国,由于原虫对甲氟喹的敏感性降低而需增加剂量。作者于1990—1994年在泰国通过治疗前后的对照实验,观察副作用的发生率及持续时间,以评价大剂量甲氟喹治疗的优缺点。 In many areas mefloquine is used to treat or prevent falciparum malaria, this drug is especially effective against multi-drug resistant protozoa strains whose adverse reactions are limited to the gastrointestinal tract and are minor. In some areas, such as Thailand, the dose needs to be increased due to the reduced susceptibility of protozoal to mefloquine. The author in 1990-1994 in Thailand through the control before and after treatment experiments to observe the incidence and duration of side effects in order to evaluate the advantages and disadvantages of high-dose mefloquine.