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本文采用荧光偏振免疫分析法（ＦＰＩＡ）在健康家兔体内考察了倍他乐克对氨茶碱药动学参数的影响。结果表明，倍他乐克可使氨茶碱的分布容积减少（Ｐ＜０．０１），而对茶碱的消除速率常数Ｋ，血药浓度曲线下面积ＡＵＣ未见影响（Ｐ＞０．０５）。
In this paper, the effects of metoprolol on pharmacokinetics of aminophylline were investigated in vivo in healthy rabbits by fluorescence polarization immunoassay (FPIA). The results showed that metoprolol decreased the distribution volume of aminophylline (P <0.01), but had no effect on the elimination rate constant of theophylline K and the area under the plasma concentration curve AUC (P> 0.05 ).