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目的探讨泛耐药鲍曼不动杆菌(XDR-AB)感染的治疗方案及临床药师在重症感染病例救治中的作用。方法以1例全身多部位(皮肤、肺部、颅内、血液)感染XDR-AB的患者为例,介绍临床药师根据患者病情变化协助医师制定抗感染治疗方案,分析并讨论XDR-AB的防控与治疗。结果患者的感染得到有效控制,治疗过程中无明显药物不良反应发生。结论以多黏菌素(鞘内+静滴)为基础的联合治疗方案可能是治疗XDR-AB颅内、血流感染的有效方案。加强感染防控,探索和优化抗感染治疗策略,加强多学科的协作,对提高治愈率有重要意义。
Objective To investigate the treatment of pan-drug-resistant Acinetobacter baumannii (XDR-AB) infection and the role of clinical pharmacists in the treatment of severe infections. Methods A case of XDR-AB infected by multiple body parts (skin, lung, intracranial, and blood) was taken as an example. Clinical pharmacists were introduced to assist physicians in formulating anti-infective therapy according to the patient’s condition. Control and treatment. Results The patient’s infection was effectively controlled and no obvious adverse drug reactions occurred during the treatment. Conclusion Combination therapy based on polymyxin (intrathecal and intravenous drip) may be an effective treatment for XDR-AB intracranial and bloodstream infections. Strengthening infection prevention and control, exploring and optimizing anti-infective treatment strategies and strengthening multidisciplinary collaboration are of great significance to improving the cure rate.