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目的 调查广州地区耐青霉素肺炎链球菌分离状况及其对8 种抗菌药物体外抗菌活性,用以指导临床治疗时抗菌药物的选择.方法 采用E?TEST 方法.结果 从临床分离的102 株肺炎链球菌中低耐药株12 株,对8 种抗菌药物中阿莫西林/ 克拉维酸钾、头孢曲松、头孢呋辛、头孢克罗、氧氟沙星等抗菌活性在敏感范围,以阿莫西林/ 克拉维酸钾和头孢曲松最敏感,对青霉素、苯唑西林、阿齐霉素耐药.结论 广州地区耐青霉素肺炎链球菌的分离率不高,但随着抗生素的广泛使用,耐药株有可能增加,应引起高度重视.“,”Objective To investigate the isolation rate and drug susceptibility of PRSP in Guangzhou and in vitro antimicrobial activities of 8 antimicrobial agents against PRSP Methods MICs were tested by E test Results Of 102 strains of Streptococcus pneumoniae, 12 strains were low level resistant against penicillin (isolation rate 11 8%) and the antimicrobial activites of 5 drugs (augmentin, cefaclor, ceftriaxone, cefuroxime, ofloxaxin) against them were within their MICs, augmentin and ceftriaxone being the most powerful They were resistant to azithromicin, oxacillin and penicillin Conclusions The isolation rate of Penicillin resistant Streptococcus pneumoniae was not high in Guangzhou, but it may increase with the extensive use of antimicrobial agents, which deserves much attention