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目的探讨前列地尔序贯疗法治疗老年临床期糖尿病肾病的临床效果。方法将2014年7月—2016年5月收治的125例老年临床期糖尿病肾病患者随机分为对照组60例和观察组65例,观察组采用前列地尔序贯疗法,对照组采用前列地尔静脉滴注疗法,比较两组总有效率、不良反应发生率、实验室检验指标,数据进行统计学处理,P<0.05为差异有统计学意义。结果观察组总有效率96.92%,对照组为85.0%,两组比较差异有统计学意义(P<0.05);观察组24 h尿蛋白、血肌酐、尿素氮、血胱抑素值均比对照组低,(t=3.689、5.213、4.352、4.663,均P<0.05)。结论对老年临床期糖尿病肾病患者采用前列地尔序贯疗法效果确切,促进患者肾功能的改善,值得临床推广。
Objective To investigate the clinical efficacy of sequential therapy of alprostadil in the treatment of diabetic nephropathy in the elderly. Methods A total of 125 elderly patients with diabetic nephropathy admitted from July 2014 to May 2016 were randomly divided into control group (n = 60) and observation group (n = 65). The observation group was treated with alprostadil sequential therapy, while the control group was treated with alprostadil Intravenous drip therapy, the two groups were compared the total effective rate, the incidence of adverse reactions, laboratory test indicators, data for statistical analysis, P <0.05 for the difference was statistically significant. Results The total effective rate was 96.92% in the observation group and 85.0% in the control group, with significant difference between the two groups (P <0.05). Urine protein, serum creatinine, urea nitrogen and serum cystatin in the observation group were significantly higher than those in the control group Group was low (t = 3.689,5.213,4.352,4.663, all P <0.05). Conclusion The clinical effect of sequential topical thalidomide in elderly patients with diabetic nephropathy is effective and can promote the improvement of renal function. It is worth to be clinically promoted.