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本文对９０例大肠癌、１０１例大肠癌断端及１５例正常大肠粘膜组织用单克隆抗体ＰＣ１０经ＳＡＢＣ免疫组化法进行ＰＣＮＡ指数测定。结果显示：ＰＣＮＡ指数在正常大肠粘膜组织为零，在大肠癌组织为１００％表达，均值为５１．４％，在大肠癌断端为８０．２％表达，均值为１９．４％；大肠癌ＰＣＮＡ指数的高低似与病程进展有关，大肠癌ＤＵＫＥ分期Ａ期和Ｂ期者ＰＣＮＡ指数显著低于ＤＵＫＥＣ期或Ｄ期者；大肠癌ＰＣＮＡ指数大小似与肿瘤的预后有关，术后３年未复发者ＰＣＮＡ指数均值在癌组织为３８．８％，在切除断端为３．５％，显著低于术后复发、转移或因癌死亡者在癌区６７％和断端３９．８％的ＰＣＮＡ指数均值。本结果提示ＰＣＮＡ指数均值与大肠癌分化程度无明显平行关系，这是独立于肿瘤分化程度的另一个判断预后的指标
In this paper, the PCNA index was determined by SABC immunohistochemistry on monoclonal antibody PC10 in 90 cases of colorectal cancer, 101 cases of colorectal cancer and 15 cases of normal colorectal mucosa. The results showed that PCNA index was zero in normal colorectal mucosa, 100% in colorectal cancer tissues, with an average of 51.4%, and 80.2% in colorectal cancer. The mean value was 19.4%; colorectal cancer The PCNA index seems to be related to the progression of the disease. The PCNA index of DUKE stage A and B colorectal cancer was significantly lower than that of DUKEC or D stage. The PCNA index of colorectal cancer was similar to the prognosis of the tumor and did not recur after 3 years. The mean PCNA index was 38.8% in cancerous tissue and 3.5% in resecting stenosis, which was significantly lower than postoperative recurrence, metastasis, or cancer death in the cancer area of 67% and 39.8% of the PCNA in the stump. Average value of the index. The results suggest that there is no significant parallel relationship between the mean PCNA index and the degree of differentiation of colorectal cancer. This is another indicator of prognosis independent of the degree of tumor differentiation.