论文部分内容阅读
目的了解阴洁尔康洗液的杀菌及毒性性能。方法依据卫生部《消毒技术规范》进行悬液定量杀菌实验及毒理实验。结果阴洁尔康洗液原液作用2 min,对金黄色葡萄球菌和大肠杆菌的杀灭率为100.00%、对白色念珠菌的杀灭率为99.98%;含体积分数25%的小牛血清对阴洁尔康洗液杀菌作用有中度影响,将该洗液置54℃恒温箱中存放14 d,有效成分的含量下降率为2.50%。阴洁尔康洗液的小鼠经口LD50>5 000 mg/kg,属实际无毒级,该洗液原液对家兔皮肤和阴道黏膜无刺激性。结论阴洁尔康洗液对细菌繁殖体、白色念珠菌具有一定的杀菌作用,动物毒性实验属实际无毒级,对家兔皮肤和阴道黏膜无刺激性,储存性能稳定。
Objective To understand the bactericidal and toxic properties of Yin Jie Er Kang lotion. Methods According to the “Technical Specifications of Disinfection” of Ministry of Public Health, quantitative suspension sterilization experiments and toxicological experiments were carried out. The results of the Yin Jie Er Kang lotion solution for 2 min, the Staphylococcus aureus and Escherichia coli killing rate was 100.00%, Candida albicans kill rate was 99.98%; containing 25% of the volume fraction of calf serum pairs Yin Jie Er Kang lotion bactericidal effect has a moderate effect, the lotion was placed 54 ℃ incubator stored 14 d, the active ingredient content decreased 2.50%. Yin Jie Er Kang lotion mice oral LD50> 5 000 mg / kg, is an actual non-toxic grade, the lotion liquid on rabbit skin and vaginal mucosa non-irritating. Conclusion Yin Jie Er Kang lotion on bacteria propagules, Candida albicans has a certain bactericidal effect, animal toxicity test is a practical non-toxic grade, non-irritating to the rabbit skin and vaginal mucosa, storage stability.